This keynote will explore emerging research on cannabis consumption methods, highlighting how chemistry can help distinguish between smoking, vaping, and edibles, and how these differences shape individual experiences. Dr. Riley Kirk will present data on dosing with specific cannabis profiles and discuss how tailored approaches may benefit people managing anxiety, pain, or insomnia. The talk will also address the barriers to cannabis research created by federal restrictions and share innovative strategies researchers are using to collect meaningful, real-world data despite these challenges.